New Thermo Scientific B·R·A·H·M·S PCT direct blood test allows fast bacterial infection and sepsis diagnosis at patient’s point of care

The new B·R·A·H·M·S PCT direct point of care assay requires just one drop of blood for a reliable infection diagnosis and clinical decisions in the acute care setting within 20 minutes

HENNIGSDORF, GERMANY – July 17, 2018 –The new B·R·A·H·M·S PCT direct point of care assay is designed to make procalcitonin (PCT) measurement available to acute care settings where easy handling, quick and precise results are required to support timely clinical decisions, in conjunction with other clinical findings. Compared with established automated B·R·A·H·M·S PCT laboratory assays the new B·R·A·H·M·S PCT direct assay shows a close analytical correlation with both venous and capillary blood and can therefore be applied in early diagnosis of bacterial infection and sepsis, in decisions whether or not to start antibiotics and for monitoring the antibiotic therapy. Moreover, its short total turnaround time of 25 minutes (20 minutes test performance and 5 minutes handling time) makes it five times quicker than sending the request to the laboratory 1. The B·R·A·H·M·S PCT direct assay requires just a drop of whole blood and is beneficial for patients where sample volume may be an issue.

"In the acute care setting, such as the emergency department, short decision processes and unplanned situations are the rule rather than the exception. The B·R·A·H·M·S PCT direct assay fits in very well and can provide a PCT test result in a quick, easy and precise way at any time at the point of care, even at the triage nurse room", said professor Pierre Hausfater, head of the academic emergency department at Pitié-Salpêtrière hospital in Paris, France.

"We are proud to launch this new version encompassing the proven B·R·A·H·M·S PCT assay quality in a format which enables easy, fast access to the established biomarker procalcitonin in various settings including the emergency room from just a simple fingerprick", said Christophe Fraudeau, vice president and general manager, Biomarkers, for Thermo Fisher Scientific. "Earlier identification of sepsis improves patient care and is the key to rational antibiotic use for reducing antibiotic resistances."

Early detection and diagnosis of sepsis is key for the improved outcome of patients with sepsis where every hour counts 2. Procalcitonin is considered the most reliable and specific biomarker for the early diagnosis of clinically relevant bacterial infections 3-6. The B·R·A·H·M·S PCT direct assay is independent from the laboratory service and can provide a reliable PCT test result near the patient, 24/7.

This product is not available for sale in the U.S. Availability of this product depends on the regulatory marketing authorization status in the countries where the product is sold. For more information, please see the following site: www.thermoscientific.com/procalcitonin.

About Thermo Fisher Scientific

Thermo Fisher Scientific Inc. is the world leader in serving science, with revenues of more than $20 billion and approximately 70,000 employees globally. Our mission is to enable our customers to make the world healthier, cleaner and safer. We help our customers accelerate life sciences research, solve complex analytical challenges, improve patient diagnostics, deliver medicines to market and increase laboratory productivity. Through our premier brands – Thermo Scientific, Applied Biosystems, Invitrogen, Fisher Scientific and Unity Lab Services – we offer an unmatched combination of innovative technologies, purchasing convenience and comprehensive services. For more information, please visit www.thermofisher.com.

References

1. Kutz A et al., Crit Care 2013; 17 R2 91
2. Kumar A et al., Crit Care Med 2006; 34(6): 1589-96
3. Harbarth S et al., Am J Respir Crit Care Med 2001, 164: 396-402
4. Hausfater P et al., Crit Care 2007; 11(3): R60
5. Prkno A et al., Crit Care 2013; 17 R291
6. Schuetz P et al., Clin Infect Dis 2012; 55(5): 651-62

 

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Thermo Fisher Scientific Announces Sixth Licensing Agreement for B·R·A·H·M·S PCT

Siemens Healthineers Recent FDA Clearance of the Atellica IM B·R·A·H·M·S PCT Assay Extends Access of Procalcitonin to More U.S. Laboratories

WALTHAM, Mass., Oct. 2, 2018 –Thermo Fisher Scientific Inc., today announced the sixth licensing agreement for its B·R·A·H·M·S PCT (procalcitonin) biomarker that provides information on the presence and severity of bacterial infections. B·R·A·H·M·S PCT aids physicians in emergency departments (ED), intensive care units (ICU) and other hospital specialties in deciding whether to initiate antibiotic therapy in patients with suspected or confirmed lower respiratory tract infections (LRTI) and when to safely discontinue antibiotics in patients with LRTI and sepsis. Siemens Healthineers joins a leading group of healthcare technology partners that includes Abbott, bioMérieux, DiaSorin, Fujirebio and Roche, all of whom are dedicated to continued innovation to aid in early sepsis detection and reducing inappropriate antibiotic use in hospital patients.

Siemens Healthineers Atellica IM B·R·A·H·M·S PCT assay received FDA clearance on July 16, 2018. In clinical studies, B·R·A·H·M·S PCT has been shown to reduce the antibiotic prescription rate and duration in patients with LRTIs such as community-acquired pneumonia (CAP), acute bronchitis, and acute exacerbation of chronic obstructive pulmonary disease (AECOPD). Evaluating the decline in B·R·A·H·M·S PCT levels over time aids clinicians in determining whether to discontinue antibiotic therapy for patients with LRTI or sepsis. The Atellica IM B·R·A·H·M·S PCT assay can also aid in decision making on antibiotic discontinuation for patients with suspected or confirmed sepsis, assessing the risk of critically ill patients who progress from severe sepsis to septic shock, and help determine the 28-day all-cause mortality risk in sepsis patients.

The value provided by the B·R·A·H·M·S PCT biomarker is underscored by the FDA's recent clearance of extended claims. In 2016, the biomarker was cleared to use in assessing the risk of critically ill patients who were diagnosed with severe sepsis or septic shock and to help determine the 28-day all-cause mortality risk in sepsis patients. This clearance served to expand use of the biomarker outside of ICU into the ED and General Ward for sepsis and all risk mortality. In 2017, the biomarker was cleared to assist in decision making on antibiotic therapy for patients with suspected or confirmed LRTI in an inpatient setting or an emergency department and to aid in decision making on antibiotic discontinuation for patients with suspected or confirmed sepsis.

"The Siemens Healthineers Atellica IM B·R·A·H·M·S PCT assay is another example of our commitment to precision medicine and to delivering a comprehensive assay menu for the Atellica Solution," said Andy Olen, senior vice president, Laboratory Diagnostics, North America, Siemens Healthineers. "The Atellica IM B·R·A·H·M·S PCT assay is a good tool as an aid in sepsis assessment, assigning mortality risk, and antibiotic therapy decision making in the ED and ICU. Early diagnosis and treatment of sepsis is associated with better patient outcomes."

"With more than 5,000 customers in 130 countries it is clear that expanding availability of the PCT biomarker benefits patients and communities," said Patrick Durbin, senior vice president and president of specialty diagnostics for Thermo Fisher Scientific. "B∙R∙A∙H∙M∙S PCT offers consistent results across all platforms and helps health care practitioners make safe clinical decisions as they determine whether to initiate, and when to stop, antibiotic therapy in certain patients."

About B·R·A·H·M·S PCT (Procalcitonin)

B·R·A·H·M·S PCT is the first and leading procalcitonin (PCT) assay cleared for clinical use in the U.S. In use in many European countries since 1996, the value of B·R·A·H·M·S PCT in supporting care of critically ill and septic patients has been reinforced through more than 4000 publications in the U.S. and in Europe. PCT is included in antibiotic stewardship guidelines issued by IDSA (Infectious Disease Society of America) and the Surviving Sepsis Campaign.1,2

Availability of this product in each country depends on local regulatory marketing authorization status. For more information, please see the following site: About Sepsis.

About Thermo Fisher Scientific

Thermo Fisher Scientific Inc. is the world leader in serving science, with revenues of more than $20 billion and approximately 70,000 employees globally. Our mission is to enable our customers to make the world healthier, cleaner and safer. We help our customers accelerate life sciences research, solve complex analytical challenges, improve patient diagnostics, deliver medicines to market and increase laboratory productivity. Through our premier brands – Thermo Scientific, Applied Biosystems, Invitrogen, Fisher Scientific and Unity Lab Services – we offer an unmatched combination of innovative technologies, purchasing convenience and comprehensive services. For more information, please visit www.thermofisher.com.

1 Surviving Sepsis Campaign: International Guidelines for Management of Severe Sepsis and Septic Shock: 2016.

2 Barlam T, et al., Guideline for Implementing an Antibiotic Stewardship Program, Infectious Diseases Society of America, CID 2016:62.

 

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Thermo Fisher Scientific Trial Design Helps Accelerate FDA clearance process for B·R·A·H·M·S PCT license partners

Innovative banked specimen trial design aids in streamlining regulatory review for two license partners, achieving clearance in 90 days

WALTHAM, Mass. – (July 7, 2016) – Thermo Fisher Scientific, Inc., the world leader in serving science, today announced it pioneered an innovative trial design that helped its license partners, Roche Diagnostics USA and bioMérieux, achieve FDA clearance in just 90 days for the Roche ELECSYS B·R·A·H·M·S PCT and bioMérieux VIDAS B·R·A·H·M·S PCT assays. Together with the Thermo Scientific B·R·A·H·M·S PCT sensitive KRYPTOR, these are the only procalcitonin (PCT) assays cleared for clinical use in the U.S. PCT is a sensitive and specific biomarker of the inflammatory response to bacterial infection
associated with sepsis.1

The novel trial design leveraged banked specimens from Thermo Fisher Scientific’s U.S. multicenter Procalcitonin MOnitoring SEpsis Study (MOSES). Using the same patient samples from the MOSES study enabled a “universal analysis” approach to demonstrate substantial equivalence of the partners’ assays to Thermo Fisher’s previously cleared B·R·A·H·M·S PCT sensitive KRYPTOR. This enabled Roche and bioMérieux to file for clearance without the significant time and expense required to conduct their own clinical trials.

All assays produced under the B·R·A·H·M·S PCT brand utilize the same standardized reference, ensuring high concordance at clinically relevant cutoffs, regardless of platform. The clinical value of B·R·A·H·M·S PCT has been demonstrated through seven years of use in the U.S. and 20+ years of use outside the U.S., supported by an evidence base of more than 3,500 published studies.

“Thermo Fisher Scientific is committed to aiding in the fight against sepsis. This innovative approach to accelerating and expanding PCT market availability is just one more example of this commitment,” said Marc R. Tremblay, President, Clinical Diagnostics Division at Thermo Fisher Scientific. “We congratulate Roche Diagnostics USA and bioMérieux, and we look forward to working with our other license partners to further expand clinicians’ access to this valuable tool for septic patient management.”

About the MOSES Study

The 2015 Procalcitonin MOnitoring SEpsis Study (MOSES) was conducted to validate the use of B·R·A·H·M·S PCT (procalcitonin) in assessing the all-cause mortality risk of patients with sepsis. The study included 858 adult patients with sepsis recruited across 13 investigational sites in the U.S. The study found that the change in PCT over time aids in assessing cumulative 28-day risk of all-cause mortality for patients diagnosed with severe sepsis or septic shock. The study also found a 2-fold risk of death for individuals with a decrease in PCT less than or equal to 80% compared with those with a PCT decrease of more than 80% during the first four days following ICU admission. In addition, a baseline PCT measurement greater than 2.0 ng/mL is an additional factor to consider when evaluating PCT measurements on subsequent days. Based on the findings of the MOSES study, the FDA expanded B·R·A·H·M·S PCT sensitive KRYPTOR clearance to include its use in mortality risk assessment over time, aiding in septic patient management.

About Sepsis

Sepsis is a systemic inflammatory response to infection with some degree of organ dysfunction that can progress to organ failure and death.2 Each year, more than 266,000 deaths in the U.S. are attributed to sepsis (2009).3 It is the sixth most common principal diagnosis in the U.S., accounting for more than 1.6 million hospital stays.3 It is the most costly inpatient diagnosis, with aggregate annual hospital costs totaling $20.3 billion (2011).4 Early identification and intervention are crucial to improving sepsis outcomes, making rapid, more reliable detection a national, if not global, imperative. About Thermo Fisher Scientific Thermo Fisher Scientific Inc. is the world leader in serving science, with revenues of $17 billion and more than 50,000 employees in 50 countries. Our mission is to enable our customers to make the world healthier, cleaner and safer. We help our customers accelerate life sciences research, solve complex analytical challenges, improve patient diagnostics and increase laboratory productivity. Through our premier brands – Thermo Scientific, Applied Biosystems, Invitrogen, FisherScientific and Unity Lab Services – we offer an unmatched combination of innovative technologies, purchasing convenience and comprehensive support. For more information, please visit www.thermofisher.com.

1. Kumar A et al: Duration of hypotension before initiation of effective antimicrobial therapy is the critical determinant of
survival in human septic shock. Crit Care Med 2006;34(6):1589-1596.
2. Vincent JL et al: Sepsis definitions: time for change. Lancet 2013;381:774-775.
3. Elixhauser A et al: Septicemia in U.S. Hospitals 2009, Statistical Brief #122. Rockville, MD: Agency for Healthcare Research
and Quality; 2011.
4. Torio CM et al: National Inpatient Hospital Costs: The Most Expensive Conditions by Payer, 2011, Statistical Brief #160.
Rockville, MD: Agency for Healthcare Research and Quality; 2013.

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U.S. Health Economic Analysis Demonstrates the Cost Reduction Impact of using B·R·A·H·M·S PCT to Support Antibiotic Stewardship Versus Standard of Care

Outcome shows a reduction in antibiotic days, shorter length of stay, shorter duration of mechanical ventilation, and fewer patients at risk for antibiotic resistance or C.difficile infection lead to incremental reduction of costs of 26 percent in sepsis and 17.7 percent in lower respiratory tract infection

WALTHAM, Mass., May 23, 2019 – A new health economic analysis published in the journal PLOS One, compared the cost impact of using B·R·A·H·M·S PCT (Procalcitonin) assays to support antibiotic stewardship decisions versus the standard of care for patients with suspected sepsis or lower respiratory tract infections (LRTI) in the United States. Procalcitonin is a biomarker that aids clinical decision-making about when to initiate and discontinue antibiotic therapy for inpatients or patients in the emergency department with suspected or confirmed LRTI. The biomarker also aids in decision making on antibiotic discontinuation for patients with suspected or confirmed sepsis. Several cost analyses have been conducted on Procalcitonin aiding in antibiotic stewardship, but none using data primarily from the United States.

More than 1.7 million people in the U.S. are diagnosed with sepsis each year1,2,3 and it is the number one cost of hospitalization in the U.S. consuming more than $27 billion each year4,5,6,7. LRTIs are among the most common reasons for antibiotic prescription8 and an estimated 30 to 85 percent of these prescriptions are unnecessary or inappropriate9-17. Even when indicated, antibiotic treatment courses often exceed recommended durations17.

A previously published health economic decision model was used to compare the costs and effects of B·R·A·H·M·S PCT assay in supporting antibiotic stewardship decisions. The analysis considered the societal and hospital perspective with a time horizon covering the length of hospital stay. The main endpoints were total costs per patient, including treatment costs and productivity losses, the number of patients with antibiotic resistance or C.difficile infections, and costs per antibiotic day avoided.

"My clinical experience is consistent with the scientific data, demonstrating how the monitoring of bacterial infections with B·R·A·H·M·S PCT assay can reduce the costs associated with the management of LRTI and sepsis patients through reductions in length of stay and antibiotic usage," said H. Bryant Nguyen, MD, John E. Peterson Professor of Medicine and Chief of Pulmonary & Critical Care Medicine at Loma Linda University, Loma Linda, California

Based on the results, the authors concluded that using B·R·A·H·M·S PCT assay to aid in decisions about antibiotic use for hospitalized patients with suspected sepsis and LRTI is associated with a reduction in antibiotic days, a shorter length of stay on the regular ward and the intensive care unit, shorter duration of mechanical ventilation, and fewer patients at risk for antibiotic resistance or C.difficile infection. Total costs in the B·R·A·H·M·S PCT assay group compared to standard care were reduced by 26.0percent in sepsis and 17.7percent in lower respiratory tract infection (total incremental costs of −$11,311 per patient and −$2,867 per patient respectively).

Availability of product in each country depends on local regulatory marketing authorization status.

About B·R·A·H·M·S PCT (Procalcitonin)

B·R·A·H·M·S PCT assay provides information on the presence and severity of bacterial infection, helping physicians in emergency departments, intensive care and other hospital units decide whether to initiate antibiotic therapy in patients with suspected or confirmed lower respiratory tract infections (LRTI) and when to safely discontinue antibiotics in patients with LRTI and sepsis. In clinical studies, B·R·A·H·M·S PCT assay has been shown to reduce the antibiotic prescription rate and duration in patients with LRTI, defined as community-acquired pneumonia (CAP), acute bronchitis, and acute exacerbation of chronic obstructive pulmonary disease (AECOPD). Evaluating the decline in B·R·A·H·M·S PCT assay levels over time aids clinicians in determining whether to discontinue antibiotic therapy for patients with LRTI or sepsis, without compromising patient safety.

About Thermo Fisher Scientific

Thermo Fisher Scientific Inc. is the world leader in serving science, with revenues of more than $24 billion and approximately 70,000 employees globally. Our mission is to enable our customers to make the world healthier, cleaner and safer. We help our customers accelerate life sciences research, solve complex analytical challenges, improve patient diagnostics, deliver medicines to market and increase laboratory productivity. Through our premier brands – Thermo Scientific, Applied Biosystems, Invitrogen, Fisher Scientific and Unity Lab Services – we offer an unmatched combination of innovative technologies, purchasing convenience and comprehensive support. For more information, please visit www.thermofisher.com.

Reference

  1. http://jamanetwork.com/journals/jama/fullarticle/2654187
  2. http://www.nejm.org/doi/full/10.1056/NEJMoa022139
  3. https://www.cdc.gov/nchs/data/databriefs/db62.pdf
  4. https://www.hcup-us.ahrq.gov/reports/statbriefs/sb204-Most-Expensive-Hospital-Conditions.pdf
  5. https://www.hcup-us.ahrq.gov/reports/statbriefs/sb225-Inpatient-US-Stays-Trends.jsp
  6. https://www.bloomberg.com/news/articles/2017-07-14/america-has-a-27-billion-sepsis-crisis
  7. http://www.journalofinfection.com/article/S0163-4453(16)30288-2/fulltext
  8. Grijalva CG, Nuorti JP, Griffin MR. Antibiotic prescription rates for acute respiratory tract infections in US ambulatory settings. JAMA 2009; 302:758.
  9. Fleming-Dutra KE, Hersh AL, Shapiro DJ, et al. Prevalence of Inappropriate Antibiotic Prescriptions Among US Ambulatory Care Visits, 2010-2011. JAMA 2016; 315:1864.
  10. Shapiro DJ, Hicks LA, Pavia AT, Hersh AL. Antibiotic prescribing for adults in ambulatory care in the USA, 2007-09. J Antimicrob Chemother 2014; 69:234.
  11. Fridkin S, Baggs J, Fagan R, et al. Vital signs: improving antibiotic use among hospitalized patients. MMWR Morb Mortal Wkly Rep 2014; 63:194.
  12. McKay R, Mah A, Law MR, et al. Systematic Review of Factors Associated with Antibiotic Prescribing for Respiratory Tract Infections. Antimicrob Agents Chemother 2016; 60:4106.
  13. Kraus EM, Pelzl S, Szecsenyi J, Laux G. Antibiotic prescribing for acute lower respiratory tract infections (LRTI) - guideline adherence in the German primary care setting: An analysis of routine data. PLoS One 2017; 12:e0174584.
  14. Silverman M, Povitz M, Sontrop JM, et al. Antibiotic Prescribing for Nonbacterial Acute Upper Respiratory Infections in Elderly Persons. Ann Intern Med 2017; 166:765.
  15. McCullough AR, Pollack AJ, Plejdrup Hansen M, et al. Antibiotics for acute respiratory infections in general practice: comparison of prescribing rates with guideline recommendations. Med J Aust 2017; 207:65.
  16. Ebell MH, Radke T. Antibiotic use for viral acute respiratory tract infections remains common. Am J Manag Care 2015; 21:e567.
  17. Hecker MT, Aron DC, Patel NP, et al. Unnecessary use of antimicrobials in hospitalized patients: current patterns of misuse with an emphasis on the antianaerobic spectrum of activity. Arch Intern Med 2003; 163:972.

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Multi-Center Clinical Study Confirms Decreased Levels of Procalcitonin as an Independent Predictor of Mortality in Patients with Severe Sepsis and Septic Shock

Results from Procalcitonin MOnitoring SEpsis Study published in May 2017 issue of Critical Care Medicine

WALTHAM, Mass. – (April 20, 2017) – Thermo Fisher Scientific Inc. today announced that results from the multi-center Procalcitonin MOnitoring SEpsis (MOSES) Study have been published in the May 2017 print issue of Critical Care Medicine. Researchers from the study, titled "Serial Procalcitonin Predicts Mortality in Severe Sepsis Patients: Results From the Multicenter Procalcitonin MOnitoring SEpsis (MOSES) Study," investigated the use of the B·R·A·H·M·S PCT (procalcitonin) assay to assess risk for 28 day all-cause mortality for patients diagnosed with severe sepsis or septic shock in 13 U.S. investigational sites.

Results from the multi-center study showed that patients with a decrease in PCT less than or equal to 80 percent during the first four days following diagnosis of severe sepsis or septic shock had a two-fold increased risk of death as compared to those who experienced a decrease in PCT greater than 80 percent1. The study also found that a baseline PCT measurement greater than 2.0 ng/mL is an additional mortality risk factor when evaluating PCT measurements on subsequent days1.

"Given the significant amount of sepsis-related deaths in the United States, there is a need for a more rigorous and effective approach to monitoring the progression of this syndrome in patients," said lead principal investigator, Nathan I. Shapiro, M.D., MPH, attending physician at the department of emergency medicine at Beth Israel Deaconess Medical Center in Boston. "Through the MOSES study, my fellow investigators and I have gained a better understanding of how serial PCT levels can be measured in a hospital setting to further risk-stratify mortality risk."

"We are proud to partner with Dr. Nathan Shapiro, Dr. Philipp Schuetz, and all the investigators of the MOSES trial, and support their initiatives in securing publication of this study," said Lonnie Shoff, President of the Clinical Diagnostics Division at Thermo Fisher Scientific. "These clinical results further validate and help shed light on the critical role PCT plays in the risk assessment for patients diagnosed with severe sepsis or septic shock. We look forward to continuing the conversation around the importance of sepsis awareness and the impact PCT can have in septic patient management."

As a result of the MOSES study, Thermo Fisher Scientific received expanded FDA clearance for its B·R·A·H·M·S PCT biomarker assay for sepsis risk assessment. Under the expanded clearance, PCT measurements can be obtained in emergency departments and hospital wards prior to admission to the intensive care unit. Additionally, the clearance helped the Thermo Fisher Scientific license partners, Roche Diagnostics USA and bioMérieux to achieve FDA clearance for the Roche ELECSYS B·R·A·H·M·S PCT and bioMérieux VIDAS B·R·A·H·M·S PCT assays in just 90 days, further expanding access to PCT in the United States. Physicians can assess the decrease in PCT levels using the online calculator at www.brahms-pct-calculator.com.

About Sepsis

Sepsis is a systemic inflammatory response to infection with some degree of organ dysfunction that can progress to organ failure and death. Each year, more than 266,000 deaths in the U.S. are attributed to sepsis (2009). It is the sixth most common principal diagnosis in the U.S., accounting for more than 1.6 million hospital stays. It is the most costly inpatient diagnosis, with aggregate annual hospital costs totaling over $23 billion (2013). Early identification and intervention are crucial to improving sepsis outcomes, making rapid, more reliable detection a national, if not global, imperative. To learn more about sepsis, please visit: www.thermofisher.com/aboutsepsis.

About Procalcitonin (PCT)

In healthy people, Procalcitonin (PCT) is produced in thyroid cells as a precursor for the hormone calcitonin and is nearly undetectable in human blood. However, bacterial infections cause PCT to be produced by almost every organ of the body, resulting in a rapid rise of PCT levels in the blood. Viral infections very rarely, and not to the same level, cause this increase in PCT blood levels. The level of PCT in the blood is a reflection of the severity of bacterial infection, ranging from slightly elevated concentrations in infections with minor systemic inflammatory response to very high values in cases of severe sepsis and septic shock. Once an infection is under control, PCT levels decrease rapidly. PCT is intended for use in conjunction with other laboratory findings and clinical assessments to aid in the risk assessment of critically ill patients on their first day of Intensive Care Unit (ICU) admission for progression to severe sepsis and septic shock.

About Thermo Fisher Scientific

Thermo Fisher Scientific Inc. is the world leader in serving science, with revenues of $18 billion and more than 55,000 employees globally. Our mission is to enable our customers to make the world healthier, cleaner and safer. We help our customers accelerate life sciences research, solve complex analytical challenges, improve patient diagnostics and increase laboratory productivity. Through our premier brands – Thermo Scientific, Applied Biosystems, Invitrogen, Fisher Scientific and Unity Lab Services – we offer an unmatched combination of innovative technologies, purchasing convenience and comprehensive support. For more information, please visit www.thermofisher.com.

1. MOSES Clinical Trial Data. On file Thermo Fisher Scientific.

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