Sepsis Definition

The Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3) 2016  Ref-1

  • Sepsis: Life-threatening organ dysfunction due to a dysregulated host response to infection (The term ‘severe sepsis’ has been deemed redundant and removed, as sepsis has a mortality rate of 10 percent or higher, making the condition already severe. The SIRS criteria have been removed as they are overly non-specific and of poor clinical utility. There is a strong focus on non-homeostatic host response to infection and infection without organ dysfunction is not a part of new sepsis definition.)

  • Septic Shock: Subset of sepsis in which particularly profound circulatory, cellular, and metabolic abnormalities substantially increase mortality

ACCP/SCCM Consensus Conference 1992 Ref-2

Definitions for the terms of "SIRS - Systemic Inflammatory Response Syndrome", "sepsis", "severe sepsis" or "septic shock" have been proposed by the ACCP/SCCM Consensus Conference in 1992, and are now widely used.

SIRS and Sepsis Definition (ACCP/SCCM-criteria) 

(Systemic Inflammatory
Response Syndrome)

2 or more of the following criteria:
• Temperature >38 °C or <36 °C
• Heart rate >90 beats/min
• Respiratory rate > 20 breaths/min or PaCO2 <32 torr (<4.3 kPa)
• WBC >12000 cells/mm3, <4000 cells/mm3, or >10% immature (band) forms


Sepsis Documented infection together with 2 or more SIRS criteria

Severe Sepsis 

Sepsis associated with organ dysfunction, including, but not limited to, lactic acidosis, oliguria, hypoxemia, coagulation disorders, or an acute alteration in mental status 

Septic Shock

Sepsis with hypotension, despite adequate fluid resuscitation, along with the presence of perfusion abnormalities. Patients who are on inotropic or vasopressor agents may not be hypotensive at the time when perfusion abnormalities are detected.

thermo scientific applied biosystems invitrogen fisher scientific unity lab service