B·R·A·H·M·S PCT (Procalcitonin): Early Infection Diagnosis in Acute Heart Failure Patients


Reliable diagnosis with B·R·A·H·M·S PCT (Procalcitonin)

Patients with Acute Heart Failure (AHF) or Lower Respiratory Tract Infection (LRTI) usually present to the Emergency Department (ED) with the common complaint of dyspnea. Including PCT in clinical diagnosis increases diagnostic certainty of pneumonia in AHF patients.


Facts on Heart Failure and Infection


Infections cause 18% of hospitalizations for acute heart failure Ref-1


Pneumonia independently associated with higher in-hospital mortality for hospitalized heart failure patients (Odds Ratio 1.60) Ref-2


AHF precipitated by Acute Coronary Syndrome (ACS) or infection is independently associated with higher 90-day risk of death (Hazard Ratio 1.51) Ref-3


B·R·A·H·M·S PCT (Procalcitonin) – the best in early diagnosis of bacterial LRTI and sepsis

ahf-accuracy-sepsis-diagnosis-pctAccuracy of sepsis diagnosis based on a clinical model with and without PCTRef-5

Procalcitonin (PCT) is a reliable blood parameter that supports earlier and better diagnosis and clinical decision-making for systemic bacterial infections and therapy control Ref-4:

  • High sensitivity and specificity for bacterial infection
  • Fast increase after bacterial infection
  • Assessment of severity of disease and prognosis

Rapid and accurate differential diagnosis is of utmost importance. Delayed targeted therapy Ref-6 or inadequate therapy Ref-7 increases the risk of adverse patient outcomes.


References B·R·A·H·M·S PCT (Procalcitonin): Early Infection Diagnosis in Acute Heart Failure Patients

Ref-1: Nieminen et al., EHJ 2006; 27: 2725-36

Ref-2: Fonarow et al., Arch Intern Med 2008; 168: 847-54

Ref-3: Arrigo et al., Eur J Heart Fail 2017 Feb; 19(2): 201-208. doi: 10.1002/ejhf.682. Epub 2016 Oct 28

Ref-4: Meisner, Procalcitonin – Biochemistry and Clinical Diagnosis, ISBN 978-3-8374-1241-3, UNI-MED, Bremen 2010

Ref-5: Harbarth et al., Am J Respir Crit Care Med 2001; 164: 396-402

Ref-6: Wuerz, Ann. Emerg. Med. 21 (1992) 669-674

Ref-7: Maisel et al., Eur J Heart Fail 2012; 14: 278-86

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