Antibiotic stewardship with help of B·R·A·H·M·S PCT (Procalcitonin)

The overuse of antibiotics is a global problem but B·R·A·H·M·S PCT assay can help guide antibiotic stewardship and reduce resistance to the effects of these drugs.

The problem: Antibiotic resistance is an increasing threat to public health

For many years the magic bullet “antibiotics” has been helping patients to survive from bacterial infections, sometimes caused by a simple wound. This has changed dramatically as antibiotic drugs have been overused. Today’s worldwide situation is that antibiotics lost their effectiveness because bacteria have learned to successfully resist the drugs: the former magic bullet remains without effect increasingly often: illnesses are prolonged while healthcare expenditures increase. Data shows that 1/3 of antibiotic prescriptions are unnecessary.

1/3 of antibiotic prescriptions are unnecessarySource: Centers for Disease Control and Prevention (CDC), Press Release, May 3, 2016:
http://www.cdc.gov/media/releases/2016/p0503-unnecessary-prescriptions.html

B·R·A·H·M·S PCT (Procalcitonin) supports responsible use of antibiotics

B·R·A·H·M·S PCT helps in two ways: The biomarker’s level can guide doctors’ decision to administer antibiotics in patients that benefit from the drugs and the individual PCT levels recommend for how long the therapy should last – of course always in conjunction with other clinical findings. Due to its high sensitivity and specificity B·R·A·H·M·S PCT therefore safely supports responsible use of antibiotics to prolong their effectiveness.

PCT-guidance for antibiotic de-escalation is also recommended in the ‘Surviving Sepsis Campaign: International Guidelines for Management of Severe Sepsis and Septic Shock: Update 2012’.

We suggest the use of low procalcitonin levels … to assist the clinician in the discontinuation of empiric antibiotics in patients who appeared septic, but have no subsequent evidence of infection.PCT-guidance for antibiotic de-escalation is recommended in the ‘Surviving Sepsis Campaign:
International Guidelines for Management of Severe Sepsis and Septic Shock: Update 2012’.

Benefits of B·R·A·H·M·S PCT in the fight against antibiotic resistance

B·R·A·H·M·S PCT assay is an effective tool to guard against misuse and overuse of antibiotics, with proven evidence in several clinical trials. The majority of these trials have been done with the B·R·A·H·M·S assay and with the antibodies that have been shared with other companies’.

B·R·A·H·M·S PCT – PCT-guidance of AB therapy has the potential to: Reduce initial prescription rates; Shorten treatment durations; Save overall treatment costsPCT-guidance of antibiotic therapy – the benefits

In addition to other clinical criteria B·R·A·H·M·S PCT supports the decision finding, be it for the start of antibiotic therapy or its safe discontinuation. As a consequence, a B·R·A·H·M·S PCT-guided algorithm helps to reduce prescriptions, shorten therapy duration and finally supports to save costs.

A B·R·A·H·M·S PCT-guided algorithm helps to guide antibiotic therapy – a great benefit in the fight against antibiotic resistance.

 

More information:

 

thermo scientific applied biosystems invitrogen fisher scientific unity lab service